Fractional exclusion statistics and shot noise in ballistic conductors

We study the noise properties of ballistic conductors with carriers satisfying fractional exclusion statistics. To test directly the nature of exclusion statistics we found that systems under weakly degenerate conditions should be considered. Typical of these systems is that the chemical potential, $\mu$ is in the thermal range $|\mu |<3k_{B}T$. In these conditions the noise properties under current saturation are found to depend upon the statistical parameter $g$, displaying suppressed shot noise for $1/2\leq g\leq 1$, and enhanced shot noise for $0<g<1/2$, according to the attractive or repulsive nature of the carrier exclusion statistics.Comment: 6 pages, 5 figures, accepted for publication in Phys. Rev.

Opsin vs opsin: new materials for biotechnological applications

The need of new diagnostic methods satisfying, as an early detection, a low invasive procedure and a cost-efficient value, is orienting the technological research toward the use of bio-integrated devices, in particular bio-sensors. The set of know-why necessary to achieve this goal is wide, from biochemistry to electronics and is summarized in an emerging branch of electronics, called \textit{proteotronics}. Proteotronics is here here applied to state a comparative analysis of the electrical responses coming from type-1 and type-2 opsins. In particular, the procedure is used as an early investigation of a recently discovered family of opsins, the proteorhodopsins activated by blue light, BPRs. The results reveal some interesting and unexpected similarities between proteins of the two families, suggesting the global electrical response are not strictly linked to the class identity.Comment: 10 pages, 8 figures revised version with more figure

Size effects on generation recombination noise

We carry out an analytical theory of generation-recombination noise for a two level resistor model which goes beyond those presently available by including the effects of both space charge fluctuations and diffusion current. Finite size effects are found responsible for the saturation of the low frequency current spectral density at high enough applied voltages. The saturation behaviour is controlled essentially by the correlations coming from the long range Coulomb interaction. It is suggested that the saturation of the current fluctuations for high voltage bias constitutes a general feature of generation-recombination noise.Comment: 3 pages, 1 figure. To appear in Applied Physics Letters (2 December 2002 issue

Noise and diffusion of particles obeying asymmetric exclusion processes

The relation between noise and Fick's diffusion coefficient in barrier limited transport associated with hopping or tunneling mechanisms of particles obeying the asymmetric simple exclusion processes (ASEP) is physically assessed by Monte Carlo simulations. For a closed ring consisting of a large number of barriers the diffusion coefficient is related explicitly to the current noise thus revealing the existence of a generalized Nyquist-Einstein relation. Both diffusion and noise are confirmed to decrease as the square root of the number of barriers as a consequence of the correlation induced by ASEP. By contrast, for an open linear chain of barriers the diffusion coefficient is found to be no longer related to current noise. Here diffusion depends on particle concentration but is independent of the number of barriers

Hierarchy and assortativity as new tools for affinity investigation: the case of the TBA aptamer-ligand complex

Aptamers are single stranded DNA, RNA or peptide sequences having the ability to bind a variety of specific targets (proteins, molecules as well as ions). Therefore, aptamer production and selection for therapeutic and diagnostic applications is very challenging. Usually they are in vitro generated, but, recently, computational approaches have been developed for the in silico selection, with a higher affinity for the specific target. Anyway, the mechanism of aptamer-ligand formation is not completely clear, and not obvious to predict. This paper aims to develop a computational model able to describe aptamer-ligand affinity performance by using the topological structure of the corresponding graphs, assessed by means of numerical tools such as the conventional degree distribution, but also the rank-degree distribution (hierarchy) and the node assortativity. Calculations are applied to the thrombin binding aptamer (TBA), and the TBA-thrombin complex, produced in the presence of Na+ or K+. The topological analysis reveals different affinity performances between the macromolecules in the presence of the two cations, as expected by previous investigations in literature. These results nominate the graph topological analysis as a novel theoretical tool for testing affinity. Otherwise, starting from the graphs, an electrical network can be obtained by using the specific electrical properties of amino acids and nucleobases. Therefore, a further analysis concerns with the electrical response, which reveals that the resistance sensitively depends on the presence of sodium or potassium thus posing resistance as a crucial physical parameter for testing affinity.Comment: 12 pages, 5 figure

Investigations on the electrical current-voltage response in protein light receptors

We report a theoretical/computational approach for modeling the current-voltage characteristics of sensing proteins. The modeling is applied to a couple of transmembrane proteins, bacteriorhodopsin and proteorhodopsin, sensitive to visible light and promising biomaterials for the development of a new generation of photo-transducers. The agreement between theory and experiments sheds new light on the microscopic interpretation of charge transfer in proteins and biological materials in general.Comment: 4 pages, 3 figures To be published in J Phys. C: Conf Ser. Proceeding of the Conference IC-MCSQUARE, PRAGUE 201